L2 hydroxyglutaric aciduria is a neurologic disease whose symptoms include wobbly walking, fits, muscle cramps and unusual behaviour. The condition is deadly to the dog.
The disease are checked through a blood test, and a dog have two copies of the affected gene, which may be Clear, Carrier or Affected.
For a dog who is affected, both parents must be Carriers of the gene. If only one parent is Carrier, the puppies may be carriers, but cannot be Affected if the other parent is Clear.
Clear: The dog has two normal copies of the gene and will not develope, nor pass on the disease to its offspring.
Carrier: The dog is carrier of the gene and has a mutated copy. It will not develope the disease, but may pass the defected gene to 50% of its offspring, that will be carriers.
Affected: The dog is affected by the disease. It has 2 copies of the mutated gene and it will develope the disease. Both parents is carriers of the genes.